Target intelligence / Profile preview

Enamel surface of tooth

Molecular classification
Other (Mineralized extracellular tissue)
01

Overview

Tooth enamel is the most mineralized and hardest tissue in the human body, covering the anatomic crown of teeth as a thin, hard, and highly mineralized layer. Composed of approximately 95–98% inorganic calcium phosphate (as carbonated hydroxyapatite), about 1% organic matrix (mainly enamel-specific proteins: amelogenin, enamelin, ameloblastin), and the remainder water, enamel provides structural integrity, mechanical protection, and resistance to wear and acid attack during chewing and exposure to foods. Enamel does not contain cells, blood vessels, or nerves, and cannot regenerate after formation. Its crystalline rods are susceptible to demineralization by acid and are thus the focus of preventive dental treatments.

Other names
EnamelTooth enamelDental enamel
02

Mechanism of action

Fluoride: promotes remineralization and inhibits demineralization of enamel hydroxyapatite; Calcium phosphate: provides ions for remineralization; Sealants: form physical barrier over enamel

03

Biological functions

Structural protection of tooth crownMechanical barrier against physical, chemical, and microbial insultProvides hardness for masticationPrevents wear and damage to deeper tooth layers (dentin, pulp)
04

Disease associations

Dental caries (decay due to enamel demineralization)Dental erosion (due to acids)Enamel hypoplasia (developmental defect)Dental fluorosis (mineralization defect)Molar hypomineralization
05

Safety considerations

Enamel is biologically inert and does not pose systemic safety concernsTopical treatments (e.g., fluoride) have toxicity risk if ingested in excessIrreversible loss: enamel cannot regenerate, so damage is permanent
06

Interacting drugs

Topical fluoride (sodium fluoride, stannous fluoride)

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