Endocannabinoid Reuptake Transporter

The endocannabinoid reuptake transporter is a putative biological system responsible for the cellular uptake and intracellular transport of endocannabinoids like anandamide (AEA) and 2-arachidonoylglycerol (2-AG). No specific transmembrane protein has been conclusively identified, but the term refers to mechanisms involving multiple carrier proteins like fatty acid-binding proteins (FABPs) and heat shock proteins (Hsp70s). By regulating ECS signaling duration and intensity, it plays a role in physiological processes, including pain sensation, appetite, mood, and memory. Inhibition of this process, achieved through eCBRIs/SERIs, increases extracellular levels of AEA/2-AG, resulting in prolonged cannabinoid receptor activation. The exact molecular identity and mechanisms involved are still under investigation.

Other names

Endocannabinoid membrane transporterEMTAnandamide membrane transporterAMT

Inhibition of endocannabinoid uptake, leading to increased extracellular endocannabinoid levels and prolonged cannabinoid receptor activation.