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Target intelligence / Profile preview
Endocannabinoid System (ECS)
- Target
- ECS
- Molecular classification
- Neuromodulatory System, Lipid Signaling System
01
Overview
The endocannabinoid system (ECS) is a complex neuromodulatory network involved in maintaining physiological homeostasis across various systems, including the nervous, immune, and endocrine systems. It comprises endocannabinoids, cannabinoid receptors (CB1 and CB2), and enzymes responsible for their synthesis and degradation. The ECS regulates a wide range of functions, including appetite, pain, mood, memory, and immune response. Dysregulation of the ECS has been implicated in various diseases, making it a potential therapeutic target.
- Other names
- Endogenous cannabinoid system
02
Mechanism of action
Endogenous ligands (endocannabinoids) bind to cannabinoid receptors (CB1 and CB2) and other related receptors, modulating downstream cellular pathways. Exogenous cannabinoids (e.g., THC) mimic the action of endocannabinoids, primarily activating CB1 receptors.
03
Biological functions
Homeostasis RegulationAppetite RegulationMetabolism RegulationPain ModulationMood RegulationMemory and LearningImmune Response ModulationSleep/Wake Cycle RegulationStress Response RegulationNeurotransmitter Release Modulation
04
Disease associations
Chronic PainInflammationNeurodegenerative DiseasesCancerAnxietyDepressionSleep DisordersMetabolic Disorders
05
Safety considerations
Psychoactive effects (THC)Impaired cognitive functionCardiovascular effectsDrug interactionsTolerance and dependenceImmunosuppression
06
Interacting drugs
Tetrahydrocannabinol (THC)
4 more in the full profile.
07
Biomarkers
Endocannabinoid levels (AEA, 2-AG)Cannabinoid receptor expressionFAAH activityMAGL activity
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