Target intelligence / Profile preview

Endocytic pathway protein (PfEHD)

Target: PfEHD
Molecular classification: Eps15 Homology Domain-containing Proteins, ATPase

Overview

PfEHD is an Eps15 homology domain-containing protein in *Plasmodium falciparum* involved in the generation of endocytic vesicles at the parasite plasma membrane. It is essential for nutrient uptake and parasite survival within red blood cells, making it a potential antimalarial drug target.

Other names: Eps15 Homology Domain-containing Protein

Mechanism of action

Inhibition of PfEHD would block endocytosis and nutrient uptake, impairing parasite survival.

Biological functions

EndocytosisVesicle formationNutrient uptakeMembrane trafficking

Disease associations

Infection

Safety considerations

Selectivity for parasite PfEHD over host cell EHD proteins to avoid off-target effects.Potential for resistance development.

Beyond the preview

Go deeper on Endocytic pathway protein (PfEHD).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Endocytic pathway protein (PfEHD).

Explore the full profile