Endocytosis induction via mechanical stress

Endocytosis induction via mechanical stress refers to the cellular process whereby mechanical stimuli (such as changes in membrane tension, rigidity, extracellular matrix stiffness, and fluid flow/shear stress) modulate the internalization of molecules, proteins, and lipids through endocytic pathways. This can involve clathrin-mediated endocytosis, caveolae, or other routes, with core molecules and mechanisms including actin cytoskeleton remodeling, adaptor proteins, and mechanosensitive signaling pathways. This process enables rapid cellular adaptation to the mechanical microenvironment, is essential in physiological processes such as nutrient uptake and tissue maintenance, and is implicated in diseases like atherosclerosis and cancer[1][2][5][6][7].

Other names

Mechanoregulation of endocytosisMechanosensitive endocytosisMechanically induced endocytosis