Endogenous adult stem cell mobilization

Endogenous adult stem cell mobilization" refers to the activation and recruitment of adult stem cells, particularly from the bone marrow and, to a lesser extent, adipose tissue and other organs, into the peripheral blood for the purpose of tissue repair and regeneration. This process is commonly stimulated pharmacologically using agents such as granulocyte colony-stimulating factor (G-CSF) and plerixafor (AMD3100), which disrupt retention signals or otherwise activate stem cell proliferation and release. Mobilized stem cells can then travel to sites of injury or degeneration to contribute to tissue healing. This approach is being explored for a wide range of degenerative diseases and as an adjunct to regenerative medicine and cell therapy, but it does not denote a single molecular entity—rather, it is a therapeutic strategy leveraging multiple molecular and cellular pathways[1][2][3].

Other names

Endogenous stem cell mobilizationAdult stem cell mobilizationESCM

Stimulation of stem cell egress from bone marrow or other niches to peripheral blood by disrupting retention signals or enhancing chemotaxis (e.g., inhibition of CXCR4-SDF1 interaction by AMD3100; stimulation of progenitor cell proliferation by G-CSF)