Endogenous antioxidant enzyme system (None)

Endogenous antioxidant enzyme system refers to multiple enzymes produced by the body, notably superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), thioredoxin, and peroxiredoxins, among others[1][2]. These enzymes detoxify reactive oxygen species (ROS), protect biomolecules from oxidative damage, and are vital for cellular health and adaptive responses to stress[1][2][3]. Deficiencies or dysfunctions are implicated in many diseases associated with oxidative stress, including cardiovascular, neurodegenerative, inflammatory, and metabolic disorders[3]. The term does not refer to a specific protein, but rather to an entire biochemical defense network within cells; accordingly, it should be replaced by the name of a specific enzyme when structured information is required.

Other names

Antioxidant enzyme systemCellular antioxidant enzymesEndogenous enzymatic antioxidantsSuperoxide dismutaseCatalaseGlutathione peroxidaseGlutathione reductaseThioredoxinPeroxiredoxin

For relevant drugs and compounds: Enzyme induction (upregulating the expression or activity of antioxidant enzymes), Enzyme mimetic action (providing synthetic molecules that mimic natural antioxidant enzymes), Cofactor supplementation (providing nutrients required for enzyme activity, e.g., selenium, riboflavin, amino acids), Direct scavenging of ROS