Endogenous Cardiac Repair Pathways

Endogenous Cardiac Repair Pathways refer to the diverse set of biological, cellular, and molecular processes involved in the heart’s limited capacity to repair or regenerate tissue after injury such as myocardial infarction. These pathways involve the activation and participation of cardiac progenitor cells, proliferation of existing cardiomyocytes, recruitment of stem cells from peripheral sources (e.g., bone marrow), endothelial and lymphatic remodeling, and extensive paracrine signaling. Unlike traditional drug targets—which are specific proteins, receptors, or enzymes—this concept is an umbrella term for multiple, overlapping mechanisms and cell types that together represent potential points for therapeutic intervention in regenerative cardiology[1][2][3][4][5]. This term does not refer to a specific gene, receptor, or molecular target; therefore, it is inappropriate as a direct therapeutic target listing. More precise targets would be individual signaling pathways, cell surface receptors, growth factors, or cell types involved in the broader process of endogenous cardiac repair.

Other names

Endogenous cardiac regeneration pathwaysIntrinsic cardiac repair mechanismsEndogenous heart repair pathways