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Target intelligence / Profile preview
Endogenous Dendritic Cell (DC)
- Target
- DC
- Molecular classification
- Antigen-presenting cell, Immune cell
01
Overview
Endogenous dendritic cells (DCs) are a type of antigen-presenting cell (APC) that play a central role in both the innate and adaptive immune systems. They act as sentinels, detecting pathogens and environmental signals, processing antigens, and presenting them on their surface to T cells, thereby initiating and shaping immune responses. They comprise several subpopulations with distinct phenotypes and functions, and can be tolerogenic under certain conditions. In pathological settings they can support tumor growth, while in infections they are critical for pathogen recognition and immune priming.
- Other names
- Dendritic CellAntigen-Presenting Cell
02
Mechanism of action
N/A
03
Biological functions
Antigen presentationT cell activationImmune responseImmune modulationCytokine secretionTolerogenic function
04
Disease associations
CancerInfectionInflammationAutoimmunity
05
Safety considerations
Cytokine stormAutoimmunitySuppression of anti-tumor immunityExacerbation of infections
06
Interacting drugs
TLR agonists
4 more in the full profile.
07
Biomarkers
MHC class IICD11cCD40CD80CD86
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