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Target intelligence / Profile preview
Endogenous Enkephalins and Endorphins (N/A)
- Target
- N/A
- Molecular classification
- Neuropeptides, Opioid Peptides
01
Overview
Endogenous enkephalins and endorphins are opioid peptides naturally produced in the body that function as neuromodulators and hormones. They modulate pain, induce euphoria, regulate stress response, influence reward pathways, and affect gastrointestinal motility. They are derived from precursor proteins like proenkephalin (PENK) and proopiomelanocortin (POMC), and act primarily at μ-, δ-, and κ-opioid receptors. They play critical roles in normal physiology and in pathological states such as addiction, mood disorders, and chronic pain.
- Other names
- Endogenous Opioid PeptidesEnkephalinsEndorphins
02
Mechanism of action
Opioid receptor antagonism (e.g., naltrexone)
03
Biological functions
AnalgesiaEuphoriaStress ResponseReward ProcessingGastrointestinal Motility RegulationNeuroprotectionNeuromodulationHormonal Regulation
04
Disease associations
AddictionMood DisordersChronic Pain SyndromesAlcohol Use Disorder
05
Safety considerations
Adverse effects associated with exogenous opioids
06
Interacting drugs
Naltrexone
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