Endogenous hippocampal neurogenesis

Endogenous hippocampal neurogenesis refers to the natural generation of new neurons from neural stem cells within the adult mammalian hippocampus, particularly in the dentate gyrus. This ongoing developmental process is regulated by both intrinsic genetic programs and extrinsic environmental factors such as exercise, enriched environments, injury, stress, aging-related changes in chemokines/cytokines (e.g., CCL11, IL‑1β), and synaptic activity associated with learning. While it plays important roles in cognitive function—including learning and memory—and may be implicated in various neurological diseases or age-related cognitive decline, it is not a discrete molecular target like a receptor or enzyme but rather a complex biological phenomenon involving multiple cell types and signaling pathways.[1][2][3]

Other names

Adult hippocampal neurogenesisHippocampal neurogenesisNeurogenesis in the dentate gyrus (DG)Endogenous adult neurogenesis