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Endogenous neurogenesis
- Molecular classification
- Other
01
Overview
Endogenous neurogenesis refers to the process by which new neurons are generated from endogenous neural stem or progenitor cells within the adult brain, primarily in two regions: the subventricular zone (SVZ) and the subgranular zone (SGZ) of the hippocampus[1][2][3][5]. These stem or progenitor cells can proliferate, migrate, and differentiate into neurons and glial cells, contributing to neural plasticity, memory, and brain repair. Modulating endogenous neurogenesis is a major area of research for regenerative medicine in neurodegenerative diseases and brain injury, but it is not a discrete molecular drug target[1][3][5].
- Other names
- Adult neurogenesisNeural regenerationEndogenous neural regenerationIn situ neurogenesis
02
Mechanism of action
Enhancement of proliferation, differentiation, or survival of neural stem/progenitor cells; Modulation of signaling pathways involved in neurogenesis (e.g., serotonin signaling, BDNF-TrkB signaling, Wnt, Shh)
03
Biological functions
Neuronal developmentBrain plasticityLearning and memoryMood regulationNeural repair and regeneration
04
Disease associations
Neurodegenerative disease (e.g., Alzheimer's, Parkinson’s)DepressionStrokeTraumatic brain injuryEpilepsyAging-related cognitive decline
05
Safety considerations
Uncontrolled proliferation could risk tumorigenesis (cancer)Potential for inappropriate integration of new neuronsLack of functional integration in neurological repairSystemic modulation may have off-target effects
06
Interacting drugs
Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine
5 more in the full profile.
07
Biomarkers
Doublecortin (DCX)Ki-67Sox2BrdUNestinNeuN
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