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Target intelligence / Profile preview
Endogenous Ouabain (EO)
- Target
- EO
- Molecular classification
- Steroid hormone, Endogenous ligand
01
Overview
Endogenous ouabain (EO) is a steroid hormone that acts as an inhibitor and signaling molecule through binding to the Na⁺/K⁺-ATPase pump. It plays a role in sodium homeostasis, vascular smooth muscle contractility, and blood pressure regulation. Elevated levels are associated with hypertension.
- Other names
- OuabainEndogenous digitalis-like factor (EDLF)
02
Mechanism of action
Inhibition of Na⁺/K⁺-ATPase, activation of downstream signaling pathways (e.g., cSrc)
03
Biological functions
Na⁺/K⁺-ATPase inhibitionSignal transductionSodium homeostasis regulationVascular tone regulation
04
Disease associations
HypertensionCardiovascular diseaseSalt-sensitive hypertension
05
Safety considerations
Potential for off-target effects on Na⁺/K⁺-ATPase in other tissuesCardiac toxicity at high concentrations
06
Interacting drugs
Ouabain
1 more in the full profile.
07
Biomarkers
Plasma ouabain levels
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