Endogenous Pancreatic Hormone Secretion

Endogenous pancreatic hormone secretion" refers to the physiologic process by which the pancreatic islets of Langerhans release hormones, including insulin (from β-cells), glucagon (from α-cells), somatostatin (from δ-cells), pancreatic polypeptide (from PP cells), and ghrelin (from ε-cells)[8][9]. This secretion is tightly regulated via humoral, neural, and hormonal signals in response to metabolic state, blood nutrient levels, and neuroendocrine stimuli[1][3][7]. These hormones collectively maintain glucose and metabolic homeostasis, and their dysregulation is central to diseases such as diabetes and obesity. In summary, "Endogenous Pancreatic Hormone Secretion" is not suited to be a canonical therapeutic target as it describes an integrated physiological process involving multiple distinct hormone products and cell signaling pathways. For therapeutic or research purposes, it is advisable to specify the individual hormone or receptor of interest (e.g., "Insulin", "Glucagon-like peptide 1 receptor").

Other names

pancreatic endocrine functionpancreatic islet hormone secretionislet hormone releasepancreatic hormone release

Modulation of ion channels and exocytosis in β-cells (e.g., sulfonylureas) Potentiation of stimulus-secretion coupling via GPCRs (e.g., GLP-1 agonists) Inhibition of hormone release via somatostatin analogs