Endogenous Retinal Stem Cell Activation (ERSCA)

Endogenous retinal stem cell activation is a therapeutic strategy focused on stimulating the body's own retinal stem or progenitor cells, primarily Müller glia and ciliary epithelium-derived cells, to regenerate damaged retinal tissue. This approach involves manipulating key signaling pathways such as Notch and Wnt to induce cell proliferation, migration, and differentiation into functional retinal neurons, offering a gene-independent therapy that avoids the risks associated with cell transplantation. Challenges include limited regenerative capacity, precise control of cell fate specification, and ensuring proper integration of new neurons into the existing retinal circuitry.

Other names

Retinal RegenerationMüller Glia ActivationEndogenous Photoreceptor RegenerationIn situ retinal regeneration

Activation of endogenous retinal stem/progenitor cells (primarily Müller glia and ciliary epithelium-derived progenitors) via modulation of key signaling pathways (Notch, Wnt, EGF/FGF/Insulin) to promote proliferation, migration, and differentiation into functional retinal neurons, including photoreceptors. This aims to regenerate damaged retinal tissue without exogenous cell transplantation.