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Endoglin (CD105)
- Target
- CD105
- Molecular classification
- Type I transmembrane glycoprotein, TGF-beta receptor complex component, Receptor
01
Overview
Endoglin (CD105) is a type I transmembrane glycoprotein and a member of the TGF-beta receptor complex. It is highly expressed on proliferating vascular endothelial cells, particularly during angiogenesis, and plays a crucial role in modulating cellular responses to TGF-beta superfamily ligands. It is a therapeutic target for antiangiogenic therapies in cancer.
- Other names
- ENGENDFLJ41744HHT1ORWORW1
02
Mechanism of action
Antiangiogenic therapies targeting CD105
03
Biological functions
Signal transductionAngiogenesis regulationCell proliferationCell migrationWound healingRegulation of TGF-beta superfamily signaling
04
Disease associations
Hereditary hemorrhagic telangiectasia type I (HHT1)PreeclampsiaCancer (tumor angiogenesis)
05
Biomarkers
Tumor angiogenesis marker (CD105 expression on endothelial cells)
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