Endolysosomal membrane (null)

The endolysosomal membrane is the lipid bilayer that delimits endosomes, lysosomes, and endolysosomes in eukaryotic cells. It serves as a dynamic barrier, mediates cargo sorting, regulates the acidic environment required for enzymatic degradation, and participates in cell signaling and organelle homeostasis[2][6][7]. The composition includes numerous integral and peripheral membrane proteins (e.g., LAMP family, transporters), glycoproteins, and is characterized by the presence of unique phospholipids and cholesterol content. While essential for cellular physiology, these membranes themselves are not considered discrete drug targets; rather, dysfunction of their integrity or associated proteins is linked to numerous diseases such as lysosomal storage disorders, neurodegenerative diseases, and infectious diseases[1][2][5].

Other names

Endolysosome membraneEndolysosomal system membrane

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