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Target intelligence / Profile preview
Endometrial Lining
- Molecular classification
- Tissue, Epithelial Tissue
01
Overview
The endometrial lining, or endometrium, is the innermost mucosal layer of the uterus. It consists of epithelial cells and a supporting stroma and plays a central role in female reproductive health. The endometrium undergoes cyclical changes throughout the menstrual cycle in response to hormonal signals, primarily estrogen and progesterone. Its primary functions include preparing for embryo implantation, maintaining pregnancy, and shedding during menstruation.
- Other names
- EndometriumUterine liningInner lining of the uterus
02
Mechanism of action
Hormonal regulation of endometrial growth and shedding; SPRM modulation of progesterone receptor activity
03
Biological functions
Preparation for embryo implantationMaintenance of pregnancyMenstruationPrevention of uterine adhesions
04
Disease associations
InfertilityAbnormal uterine bleedingEndometrial hyperplasiaEndometrial cancerHeavy menstrual bleeding
05
Safety considerations
Endometrial hyperplasia due to unopposed estrogenIncreased risk of endometrial cancerSide effects of hormonal therapies
06
Interacting drugs
Estrogen
2 more in the full profile.
07
Biomarkers
Endometrial thicknessWNT7A expressionFZD2/FZD6 expressionSFRP2 expressionEstrogen receptor expressionProgesterone receptor expression
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