Target intelligence / Profile preview

Endometrial thickness (ET)

Target: ET

Overview

Endometrial thickness is the measurement (in mm) of the uterine lining by ultrasound, reflecting the proliferation and shedding of endometrial tissue in response to hormonal changes. Normal values vary by menstrual cycle phase in premenopausal women and are generally less than 4-5 mm in postmenopausal women. Elevated thickness may indicate hormonal imbalances, endometrial hyperplasia, or malignancy and is a key parameter in gynecological assessment.

Other names: Endometrial lining thicknessUterine lining thicknessET

Disease associations

Cancer (elevated endometrial thickness can indicate endometrial hyperplasia or carcinoma, especially in postmenopausal women)Abnormal uterine bleedingInfertilityHormonal imbalancesEndometrial hyperplasia

Safety considerations

Overestimation/underestimation due to technical factorsFalse positives (benign conditions can also increase thickness)Clinical thresholds for intervention are debated, especially in asymptomatic women or those on hormone/tamoxifen therapy

Biomarkers

Used as a clinical biomarker for risk stratification in endometrial hyperplasia/cancer, infertility, and response to hormonal therapy

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