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Target intelligence / Profile preview
Endoplasmic reticulum alpha-glucosidase II (Glucosidase II)
- Target
- Glucosidase II
- Molecular classification
- Enzyme, Glycoside hydrolase
01
Overview
Endoplasmic reticulum (ER) alpha-glucosidase II is a key enzyme involved in the processing of N-linked glycans on nascent glycoproteins within the ER. It acts sequentially after alpha-glucosidase I, trimming glucose residues from N-linked oligosaccharides, which is essential for proper protein folding and quality control in eukaryotic cells. It is a heterodimeric enzyme composed of an alpha (catalytic) and a beta (localization) subunit. Inhibitors targeting this enzyme can disrupt viral morphogenesis and have shown efficacy against various viruses by impairing viral protein maturation.
- Other names
- ER alpha-glucosidase IIGlucosidase II
02
Mechanism of action
Inhibition of alpha-glucosidase II, leading to disruption of N-glycan processing and glycoprotein folding
03
Biological functions
Glycoprotein processingN-glycan trimmingProtein foldingQuality controlER-associated degradation (ERAD) regulation
04
Disease associations
Viral infections
05
Safety considerations
Potential for off-target effects due to homology with other glucosidasesDisruption of host cell glycoprotein processingPotential for ER stress
06
Interacting drugs
Deoxynojirimycin (DNJ) derivatives
1 more in the full profile.
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