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Endoplasmic Reticulum Aminopeptidase 1
- Molecular classification
- Enzyme, Metalloprotease, Aminopeptidase
01
Overview
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an intracellular zinc-dependent aminopeptidase enzyme primarily located in the endoplasmic reticulum. It plays a crucial role in antigen processing and presentation, particularly for MHC class I molecules, and in the regulation of cytokine receptors. Alterations in ERAP1 function have been linked to autoimmune diseases and cancer immunity, making it a potential target for therapeutic intervention.
- Other names
- ARTS-1A-LAPPILS-APKIAA0525ERAAP
02
Mechanism of action
Inhibition of ERAP1 activity, targeting either active or regulatory sites
03
Biological functions
Antigen processingPeptide trimmingMHC-I antigen presentationCytokine receptor regulationRegulation of inflammatory signaling pathwaysImmune response
04
Disease associations
Autoimmune diseasesCancerInflammation
05
Safety considerations
Selectivity challenges due to similarity among related proteases
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