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Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3)
- Target
- ERGIC3
- Molecular classification
- Other (vesicular transport protein, membrane trafficking protein)
01
Overview
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) is a membrane-associated protein involved in vesicle-mediated transport between the endoplasmic reticulum (ER) and the Golgi apparatus[3][7]. It regulates the trafficking and positive transport of specific secretory proteins, such as alpha1-antitrypsin (SERPINA1) and haptoglobin (HP)[3][5][7]. ERGIC3 functions as part of the early secretory pathway, supporting the efficient delivery of protein cargos from the ER to the Golgi[1]. It is implicated in cancer biology, recognized as a biomarker for lung adenocarcinoma and regulated by microRNAs in cancer models[3][4]. No drugs or direct therapeutic agents are known to target ERGIC3, nor is it classified as a canonical therapeutic target such as a receptor or enzyme.
- Other names
- C20orf47ERV46SDBCAG84CGI-54PRO0989NY-BR-84dJ477O4.2ERp43serologically defined breast cancer antigen 84serologically defined breast cancer antigen NY-BR-84
02
Biological functions
Intracellular protein transportVesicular traffickingPositive regulation of secretory protein trafficking between ER and Golgi
03
Disease associations
Cancer (notably as a biomarker in lung adenocarcinoma)Other (possible circulation in cancer regulation via microRNAs)
04
Biomarkers
Biomarker of lung adenocarcinoma
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