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Target intelligence / Profile preview
Endoplasmic reticulum junction formation protein lunapark (LNPK)
- Target
- LNPK
- Molecular classification
- Other (ER-shaping membrane protein), Zinc finger-containing protein
01
Overview
Endoplasmic reticulum junction formation protein lunapark (LNPK) is a conserved ER-shaping membrane protein characterized by two transmembrane domains and a zinc finger motif that is essential for its function. LNPK localizes specifically to three-way junctions of the ER network, where it stabilizes nascent junctions and modulates ER morphology by promoting network stability and limiting excessive junction mobility. Loss or depletion of LNPK disrupts ER morphology, shifting the network from a reticulated structure toward expanded sheets, and is associated with neurodevelopmental disorders such as epilepsy and hypoplasia of the corpus callosum. Although its direct role as a therapeutic target is not established, LNPK is essential for cellular homeostasis and proper ER function[1][2][3][5].
- Other names
- Lunapark, ER junction formation factorLimb and neural patternsKIAA1715LNPLNP1NEDEHCCUlUlnaless2310011O18Rik4921514L11Rik
02
Biological functions
Maintenance of endoplasmic reticulum (ER) tubular networkStabilization of nascent three-way ER junctionsDetermination of ER morphologyPositive regulation of ER tubular network organizationLimb development (by similarity)Central nervous system development
03
Disease associations
Neurodevelopmental disorder with epilepsy and hypoplasia of the corpus callosumEpilepsy
04
Safety considerations
Depletion or loss of function leads to disruption of ER morphology (shift from tubules to sheets, ER network collapse)Potential for neurodevelopmental disorders if mutated
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