Endoplasmic reticulum lipid raft-associated protein 2 (ERLIN2)

Endoplasmic reticulum lipid raft-associated protein 2 (ERLIN2) is an integral membrane protein of the endoplasmic reticulum (ER) and a component of the ERLIN1/ERLIN2 complex, which is involved in ER-associated degradation (ERAD), particularly of inositol 1,4,5-trisphosphate receptors (IP3R)[4][6][1]. ERLIN2 is classified as an SPFH domain-containing protein and is associated with ER membrane lipid rafts, microdomains rich in cholesterol and specific proteins[6][1]. ERLIN2 is implicated in maintaining ER protein homeostasis and regulating calcium signaling. Mutations in ERLIN2 can cause autosomal dominant hereditary spastic paraplegia (SPG18), highlighting its role in neurodegeneration[1][4][6]. No drugs are currently known to directly target ERLIN2, and there is no evidence for its direct therapeutic targeting or significant safety concerns reported in the literature.

Other names

ERLIN2Erlin-2C8orf2SPFH2NET32SPG18Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2Endoplasmic reticulum lipid raft associated 2epididymis secretory sperm binding protein