Endoplasmic reticulum membrane-associated RNA degradation protein (ERMARD)

Endoplasmic reticulum membrane-associated RNA degradation protein (ERMARD) is a transmembrane protein encoded by the ERMARD (C6orf70) gene, localizing to the endoplasmic reticulum and featuring two transmembrane domains near its C-terminus. It is implicated in the process of neuronal migration during brain development, as gene knockout models in rats show impacts on this process. Mutations in ERMARD are associated with periventricular nodular heterotopia type 6 (PVNH6), a developmental malformation of the cortex characterized by misplaced neurons. The protein is not classified as a receptor, enzyme, or transporter, and its precise molecular function remains not well characterized except for an implied role in RNA surveillance or degradation at the endoplasmic reticulum, based on its name and localization. There are no approved drugs or candidate molecules that target ERMARD, and it is not considered a therapeutic target or biomarker in current medical practice.

Other names

ERMARDC6orf70PVNH6dJ266L20.3FLJ11152Endoplasmic reticulum membrane-associated RNA degradation protein

None reported; mechanisms of action for drugs are not available since ERMARD is not a known therapeutic target