Endoplasmic reticulum membrane protein complex subunit 7 (EMC7)

Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) is a subunit of the endoplasmic reticulum membrane protein complex (EMC), a multiprotein assembly that facilitates the energy-independent insertion of transmembrane domains (TMDs) into the ER membrane[2][3][1][5][4]. EMC7 forms part of the lumenal module of the EMC together with other subunits, and while it has no enzymatic activity or ligand-binding properties itself, it is crucial for the structural integrity and function of the entire EMC complex. This includes enabling the insertion and accurate folding of tail-anchored membrane proteins and multi-pass integral membrane proteins—many of which are critical for cell signaling and organelle function. Defects in EMC activity, including EMC7, are associated with impaired membrane protein biogenesis and can contribute to various disease states. However, EMC7 itself is not directly addressed as a therapeutic target, nor are drugs known to specifically target EMC7 function[2][3][4][1][5].

Other names

EMC7C11orf3C15orf24HT022UNQ905/PRO1926ORF1-FL1UPF0480 protein C15orf24Chromosome 15 hypothetical ATG/GTP binding protein

Not directly targeted by drugs and thus no defined mechanism for direct pharmacological action.