Endoplasmic reticulum protein 44 pseudogene (ENSG00000251159)

Endoplasmic reticulum protein 44 pseudogene (ENSG00000251159) is a non-functional genomic segment related by sequence to the functional ERP44 gene, which encodes a member of the protein disulfide isomerase family involved in endoplasmic reticulum function and protein quality control. As a pseudogene, this locus is generally not transcribed or translated into protein, does not have enzymatic or receptor function, and is not considered a canonical therapeutic target. While some pseudogenes can regulate gene networks or serve as competitive endogenous RNAs, there is no specific known function or disease association for this particular pseudogene. The functional ERP44 gene (not the pseudogene) encodes a protein that helps retain other ER proteins and participates in protein quality control. The pseudogene shows sequence similarity to ERP44 but lacks evidence of transcription/translation or therapeutic importance. The entry is not misspelled, but it is not a therapeutic target and there may be confusion with the functional ERP44 gene.

Other names

ERP44 pseudogeneEndoplasmic reticulum protein 44 pseudogene