Endosomal trafficking genes (ETG)

Endosomal trafficking genes refer to a broad category of genes involved in the regulation of the endocytic pathway, which manages the internalization, sorting, recycling, and degradation of proteins and lipids within cells. This group includes various protein families such as the RAB GTPases, the sorting nexins (SNX), and the vacuolar protein sorting (VPS) complexes (e.g., the Retromer complex). These genes play critical roles in cellular homeostasis by controlling the distribution of signaling receptors and the clearance of waste products. Dysregulation of endosomal trafficking is a hallmark of several pathologies, most notably Alzheimer's disease, where genes like SORL1, BIN1, and CD2AP are implicated in the faulty processing of amyloid precursor protein (APP). While individual components of this system are being explored as therapeutic targets, 'Endosomal trafficking genes' as a collective term describes a functional pathway rather than a single druggable entity.

Other names

Endosomal-lysosomal system genesEndocytic pathway genesIntracellular transport genes

Not applicable as this is a gene category rather than a single target.