Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Endosomal transmembrane epsin interactor 1 (ENTREP1)
- Target
- ENTREP1
- Molecular classification
- Other (Transmembrane protein), Endocytic adaptor protein
01
Overview
Endosomal transmembrane epsin interactor 1 (ENTREP1) is a protein-coding gene involved in cellular trafficking and signaling regulation. It functions as an activator of the E3 ubiquitin ligase ITCH and is a key effector in the ubiquitination of the CXCL12-activated CXCR4 receptor. This process leads to endocytosis and desensitization of CXCR4, thereby regulating the CXCL12/CXCR4 signaling axis, which is important in cellular migration, immune response, and cancer progression. ENTREP1 is localized to the endosome and plasma membrane and participates in adaptation of signaling pathways. Diseases associated with mutations or dysregulation of ENTREP1 include prostate cancer and progressive leukoencephalopathy with ovarian failure. Its role as an endocytic adaptor protein relates to its capability to modulate cell surface receptor turnover and cell signaling.
- Other names
- C9orf61FAM189A2EREP1
02
Mechanism of action
Modulation of receptor endocytosis (by activating E3 ubiquitin ligase, leading to receptor internalization/desensitization)
03
Biological functions
Regulation of ubiquitin ligase activityInvolvement in CXCL12-activated CXCR4 signaling pathwayNegative adaptation/desensitization of signaling pathwaysRegulation of endocytosis (especially clathrin-mediated)
04
Disease associations
Cancer (notably prostate cancer)Leukoencephalopathy with ovarian failureOther
Beyond the preview
Go deeper on Endosomal transmembrane epsin interactor 1 (ENTREP1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Endosomal transmembrane epsin interactor 1 (ENTREP1).