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Endosomal transmembrane epsin interactor 2 (ENTREP2)
- Target
- ENTREP2
- Molecular classification
- Other (integral membrane protein, not classified as GPCR, ion channel, enzyme, transporter, or classical receptor)
01
Overview
Endosomal transmembrane epsin interactor 2 (ENTREP2) is a human protein encoded by the gene ENTREP2 (also known as FAM189A1, KIAA0574, and TMEM228). It is an integral membrane protein predicted to localize to endosomal membranes, but its precise molecular function remains uncharacterized. ENTREP2 is expressed in a variety of tissues but lacks experimentally validated roles in biological processes or molecular functions in any organism studied to date. Some genetic associations connect ENTREP2 to certain syndromes, such as lung disease or chromosome breakage syndromes, but causative roles are not established and the underlying mechanisms remain to be determined. ENTREP2 is not currently considered a therapeutic target, receptor, or member of a major druggable family according to existing sources.
- Other names
- FAM189A1KIAA0574TMEM228Family with sequence similarity 189 member A1Protein FAM189A1Transmembrane protein 228
02
Biological functions
Other (predicted to be involved in or associated with endosomal/vesicular membrane processes; no experimentally confirmed molecular function or biological process in humans)
03
Disease associations
Other (associated through genetic studies with disorders including lung disease, immunodeficiency and chromosome breakage syndrome, and osteogenesis imperfecta type II; not established as a direct disease driver)
04
Interacting drugs
17beta-estradiol (predicted/ortholog evidence)
2 more in the full profile.
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