Endothelial and vascular smooth muscle cell messenger RNA

Endothelial and vascular smooth muscle cell (VSMC) messenger RNA (mRNA) refers to the collective pool of protein-coding transcripts within the two primary cell types of the vascular wall. Endothelial cells (ECs) form the interface between circulating blood and the vessel wall, playing critical roles in vasomotor tone, nutrient transport, and inflammatory responses (Source: PubMed, PMID: 30135544). VSMCs are responsible for the structural integrity and contractile function of blood vessels, and their phenotypic switching is a hallmark of vascular diseases like atherosclerosis and restenosis (Source: Nature Reviews Cardiology, 2018). While specific mRNA sequences within these cells—such as those encoding Vascular Endothelial Growth Factor (VEGF) or Nitric Oxide Synthase (eNOS)—are targeted by modern RNA-based therapeutics, the term 'Endothelial and VSMC mRNA' is too broad to be considered a single therapeutic target. It describes a biological compartment or a transcriptome rather than a discrete molecular entity. Therapeutic interventions in this space typically involve using small interfering RNAs (siRNAs) or antisense oligonucleotides (ASOs) to silence pathogenic genes, or delivering synthetic mRNA to promote the expression of therapeutic proteins (Source: Signal Transduction and Targeted Therapy, 2022).

Other names

Vascular cell mRNAEndothelial mRNAVSMC mRNAVascular transcriptome

Not applicable as a collective target; specific mRNA sequences are targeted via RNA interference (siRNA), antisense oligonucleotides (ASOs), or delivered as synthetic mRNA to induce protein expression.