Target intelligence / Profile preview

Endothelial Cell (EC)

Target: EC
Molecular classification: Cell Type, Epithelial Cell

Overview

Endothelial cells are specialized, flattened epithelial cells that form a single-cell-thick layer lining the interior surface of all blood vessels (arteries, veins, capillaries) and lymphatic vessels. This layer is known as the endothelium. The endothelium serves as a critical interface between circulating blood or lymph and surrounding tissues.

Mechanism of action

N/A

Biological functions

Barrier functionSelective permeabilityVascular tone regulationHemostasisImmune responseAngiogenesisVasculogenesisSensing mechanical forcesCommunication with smooth muscle/connective tissue

Disease associations

AtherosclerosisHypertensionThrombosisChronic inflammationCancer metastasis

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