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Target intelligence / Profile preview
Endothelial Cell Membrane
- Molecular classification
- Cell Membrane, Lipid Bilayer, Receptor, Adhesion Molecule, Enzyme, Ion Channel
01
Overview
The endothelial cell membrane is the plasma membrane of endothelial cells, forming a single-cell layer lining all blood and lymphatic vessels. It plays a central role in vascular biology, mediating barrier function, vascular tone regulation, hemostasis, inflammation, immunity, and angiogenesis. It contains various receptors, adhesion molecules, enzymes (e.g., eNOS), and ion channels.
- Other names
- Endothelium plasma membraneVascular endothelium membraneLymphatic endothelium membrane
02
Mechanism of action
Various mechanisms depending on the specific target on the membrane, including receptor-mediated endocytosis, modulation of eNOS activity, and disruption of adhesion molecule interactions.
03
Biological functions
Barrier functionVascular tone regulationHemostasisInflammationImmunityAngiogenesisSelective permeability
04
Disease associations
AtherosclerosisHypertensionThrombosisCancerInflammationEdema
05
Safety considerations
Off-target effects of drugs targeting endothelial cellsDisruption of vascular barrier functionUnintended effects on angiogenesis
06
Interacting drugs
Nitric Oxide
2 more in the full profile.
07
Biomarkers
Circulating endothelial cellsEndothelial cell adhesion moleculeseNOS activityMarkers of endothelial dysfunction
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