Endothelial cell membranes and peripheral sensory nerve endings (None)

Endothelial cell membranes form the inner lining of all blood vessels and lymphatic vessels. These cells regulate vascular permeability, blood flow, blood vessel tone, coagulation, inflammation, and angiogenesis. Dysfunction of endothelial cells is implicated in a wide range of pathologies, including cardiovascular disease, cancer, and sepsis. Peripheral sensory nerve endings are the terminal structures of sensory neurons located throughout the periphery. They detect mechanical, chemical, and thermal stimuli, converting them to electrical signals interpreted as sensations (pain, touch, temperature). As a "target," this entry is not a canonical molecular entity, but rather refers broadly to two cell membrane sites with diverse biological and therapeutic relevance.

Other names

EndotheliumSensory nerve endingPeripheral sensory terminals

For Endothelial cell membrane: Modulation of barrier permeability (VEGF inhibitors reduce leakage in tumors or retinopathies); Inhibition of angiogenesis (anti-VEGF, endostatin); Enhancement of vasodilation (nitric oxide donors); Reduction of inflammation or thrombosis. For Peripheral sensory nerve ending: Blockade of sodium channels (local anesthetics); Opioid receptor agonism; Modulation of pain signaling pathways.