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An "endothelial cell modulator" refers to any factor—molecule, receptor, or signaling pathway—that influences the function, behavior, or phenotype of endothelial cells (ECs). Endothelial cells line the interior surface of blood vessels and are critical for vascular homeostasis, regulation of vascular tone, permeability, angiogenesis (formation of new blood vessels), immune responses, and tissue regeneration.
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