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Endothelial Cell Proliferation (EC Proliferation)
- Target
- EC Proliferation
- Molecular classification
- Cellular Process
01
Overview
Endothelial cell proliferation is the multiplication of endothelial cells, essential for angiogenesis, tissue repair, and vascular development. It is tightly regulated by growth factors like VEGF and negatively regulated by factors like retinoic acid. Abnormal regulation is implicated in diseases like cancer and ischemic injury, making it a therapeutic target for both promoting and inhibiting angiogenesis.
- Other names
- AngiogenesisNeovascularizationEndothelial multiplication
02
Mechanism of action
Modulation of endothelial cell cycle progression, angiogenesis signaling pathways (e.g., VEGF/VEGFR2)
03
Biological functions
Cell proliferationAngiogenesisTissue repairVascular development
04
Disease associations
CancerAtherosclerosisWound healingIschemic injuryCardiovascular disease
05
Safety considerations
Off-target effects on normal vasculatureResistance to anti-angiogenic therapiesImpaired wound healing with excessive inhibition
06
Interacting drugs
VEGF inhibitors
1 more in the full profile.
07
Biomarkers
VEGF levelsAngiogenic markers
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