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Endothelial Cell Signaling
- Molecular classification
- Signaling pathway, Cell communication
01
Overview
Endothelial cell signaling refers to the complex network of molecular pathways and interactions that regulate the behavior, function, and communication of endothelial cells (ECs)—the cells lining the interior surface of blood vessels. These signaling mechanisms are crucial for maintaining vascular homeostasis, controlling permeability, mediating immune cell trafficking, regulating angiogenesis (formation of new blood vessels), and responding to physiological or pathological stimuli. Key pathways include Rho/Rap GTPases, Notch-Dll4/Jagged, VEGF/VEGFR, PDGFB/PDGFRβ, Angiopoietins/Tie2, Sphingosine-1-phosphate, and TGFβ.
02
Biological functions
Barrier regulationImmune traffickingAngiogenesisVascular toneHemostasisVascular patterning
03
Disease associations
Vascular leakageInflammationImpaired tissue perfusionTumor angiogenesisCardiovascular disease
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