Endothelial cell surface receptors and extracellular matrix partners

Endothelial cell surface receptors and their extracellular matrix (ECM) partners constitute a complex signaling network essential for vascular development, homeostasis, and remodeling. This group includes various receptor families such as vascular endothelial growth factor receptors (VEGFRs), integrins (e.g., alpha-V beta-3), and Tie receptors, which interact with ECM components like fibronectin, laminin, and collagen (Source: Nature Reviews Molecular Cell Biology, 2014). These interactions regulate critical processes including endothelial cell proliferation, migration, and survival, primarily through the activation of intracellular signaling cascades like the MAPK and PI3K/Akt pathways (Source: Molecular Biology of the Cell, 6th ed.). In pathological states, dysregulation of these interactions contributes to tumor angiogenesis, chronic inflammation, and cardiovascular diseases (Source: Cell, 2011). Therapeutic strategies often involve monoclonal antibodies or small molecules designed to block these interactions, thereby inhibiting aberrant vessel growth or stabilizing the vasculature. For example, drugs like bevacizumab and ramucirumab target the VEGF/VEGFR axis to inhibit tumor blood vessel formation (Source: PubMed, PMID: 25132133). However, targeting these pathways can lead to significant safety concerns, such as hypertension and impaired wound healing, due to the fundamental roles these molecules play in normal physiological maintenance.

Other names

Endothelial-ECM interactomeVascular cell surface receptorsEndothelial adhesion moleculesAngiogenic receptor complex

Inhibition of ligand-receptor binding, disruption of cell-matrix adhesion, and modulation of downstream intracellular signaling pathways (e.g., VEGF/VEGFR or Tie/Angiopoietin signaling).