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Target intelligence / Profile preview
Endothelial Cells (ECs)
- Target
- ECs
- Molecular classification
- Epithelial Cell, Cellular Barrier, Signaling Cell
01
Overview
Endothelial cells are specialized squamous epithelial cells that form a single-cell-thick layer lining the interior surface of all blood vessels and lymphatic vessels. They serve as a critical interface between circulating blood/lymph and surrounding tissues, regulating vascular tone, hemostasis, angiogenesis, and immune responses. Dysfunction or damage to endothelial cells is implicated in various diseases, making them an important therapeutic target.
- Other names
- EndotheliumVascular Endothelial CellsLymphatic Endothelial Cells
02
Mechanism of action
Varies depending on the drug. Examples include: Nitric oxide donors promote vasodilation; VEGF inhibitors block angiogenesis; ACE inhibitors affect blood pressure; Monoclonal antibodies block cell adhesion molecules, preventing endothelial cell activation.
03
Biological functions
Barrier FunctionVascular Tone RegulationHemostasisThrombosisAngiogenesisInflammationImmune ResponseEndocrine FunctionsSelective Permeability
04
Disease associations
Cardiovascular DiseaseChronic InflammationSepsisThrombosisCancer MetastasisVascular Leakage
05
Safety considerations
Off-target effects of angiogenesis inhibitorsPotential for increased bleeding with anti-thrombotic therapiesImmunogenicity of antibody-based therapiesVascular toxicity
06
Interacting drugs
Nitric Oxide Donors
4 more in the full profile.
07
Biomarkers
von Willebrand factor (vWF)CD31Circulating Endothelial Cells (CECs)Circulating Endothelial Progenitor Cells (EPCs)Angiogenic factors (e.g., VEGF)
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