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Target intelligence / Profile preview
Endothelial Glycocalyx (EG)
- Target
- EG
- Molecular classification
- Extracellular matrix component, Glycoprotein, Proteoglycan, Glycosaminoglycan
01
Overview
The endothelial glycocalyx is a carbohydrate-rich layer coating the luminal surface of vascular endothelial cells. It functions as a barrier, mediates mechanotransduction, and regulates vascular homeostasis. Its disruption is implicated in various diseases, including sepsis, atherosclerosis, diabetes, and hypertension.
- Other names
- Vascular GlycocalyxEndothelial Surface Layer
02
Biological functions
Barrier functionMechanotransductionVascular homeostasisRegulation of permeabilityModulation of coagulationModulation of inflammation
03
Disease associations
SepsisAtherosclerosisDiabetesHypertensionInflammationMicrovascular dysfunction
04
Safety considerations
Glycocalyx shedding can lead to increased vascular permeability and edema.Degradation contributes to inflammation and thrombosis.
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