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Target intelligence / Profile preview
Endothelial Lipase
- Molecular classification
- Enzyme, Lipid hydrolase, Triglyceride lipase family
01
Overview
Endothelial lipase (LIPG) is an enzyme primarily synthesized and secreted by vascular endothelial cells. It belongs to the triglyceride lipase gene family and is distinguished by its substrate specificity, preferentially hydrolyzing phospholipids on HDL, thereby influencing HDL metabolism and reverse cholesterol transport. It also contributes to the breakdown of triglyceride-rich particles. Increased expression during inflammation makes it relevant in cardiovascular diseases.
- Other names
- LIPGEndothelial lipase
02
Mechanism of action
Hydrolyzes phospholipids on HDL, accelerating HDL catabolism and clearance. Contributes to the breakdown of triglyceride-rich lipoproteins.
03
Biological functions
Lipid metabolismHDL metabolismPhospholipid hydrolysisTriglyceride hydrolysisReverse cholesterol transport
04
Disease associations
Cardiovascular diseaseAtherosclerosisMetabolic syndrome
05
Safety considerations
Lowering HDL-C levels could have unintended consequences.Potential impact on reverse cholesterol transport.
06
Biomarkers
Plasma EL levelsHDL-C levels
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