Endothelial permeability regulators

The term endothelial permeability regulators refers to a broad functional class of molecules rather than a single therapeutic target. This group encompasses a diverse array of proteins, including growth factors like Vascular Endothelial Growth Factor (VEGF), signaling lipids such as Sphingosine-1-phosphate (S1P), and structural components of the endothelial barrier like VE-cadherin and claudins. These regulators maintain the integrity of the vascular endothelium, which controls the passage of fluids, ions, and cells between the blood and surrounding tissues. Dysregulation of these pathways is a hallmark of various pathologies, including acute respiratory distress syndrome (ARDS), diabetic retinopathy, and tumor-associated edema. Because this term describes a physiological process involving multiple distinct receptors and enzymes, it is considered too broad to be classified as a specific drug target; instead, individual members of this class are targeted for therapeutic intervention.

Other names

Endothelial barrier regulatorsVascular permeability factors

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