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Endothelial Progenitor Function (EPC Function)
- Target
- EPC Function
- Molecular classification
- Cellular Function, Complex Biological Process
01
Overview
Endothelial progenitor cell (EPC) function encompasses the regenerative and repair processes of the endothelial lining of blood vessels, primarily through angiogenesis and neovascularization. EPCs, originating mainly from bone marrow, contribute to vascular repair by differentiating into endothelial cells or supporting resident endothelium via paracrine signaling. Their mobilization and function are regulated by cytokines/growth factors like VEGF, FGF, and PlGF. Impaired EPC function is linked to cardiovascular disease, while enhanced function is associated with improved outcomes after ischemic injury. Therapeutic strategies targeting EPC function are being explored for vascular injury recovery, neovascularization in ischemic tissues, and anti-cancer approaches by inhibiting tumor angiogenesis.
- Other names
- AngiogenesisNeovascularizationEndothelial Progenitor CellsEPCs
02
Mechanism of action
Modulation of EPC mobilization, differentiation, and homing to promote or inhibit angiogenesis/neovascularization.
03
Biological functions
Vascular repairAngiogenesisNeovascularizationVasculogenesisArteriogenesisParacrine signalingTissue regeneration
04
Disease associations
Cardiovascular diseaseIschemic injuryTumor growthWound healing
05
Safety considerations
Off-target effects of angiogenesis modulatorsUnpredictable differentiation and homing of EPCsPotential for promoting unwanted angiogenesis in certain contexts
06
Interacting drugs
VEGF inhibitors
2 more in the full profile.
07
Biomarkers
CD133CD34VEGFR-2/KDRCD31CD144von Willebrand factorTie2Flt1/VEGFR1CD14
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