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Target intelligence / Profile preview
Endothelial Protein C Receptor (EPCR)
- Target
- EPCR
- Molecular classification
- Type I transmembrane glycoprotein, MHC class I/CD1 family
01
Overview
Endothelial protein C receptor (EPCR), also known as activated protein C receptor or CD201, is a type I transmembrane glycoprotein primarily expressed on endothelial cells. It plays a central role in regulating blood coagulation, inflammation, and vascular integrity. EPCR binds both zymogen protein C and its active form APC with high affinity, facilitating the activation of protein C by the thrombin-thrombomodulin complex. APC bound to EPCR can activate protease activated receptor–1 (PAR1), leading to cytoprotective signaling. A soluble form of EPCR (sEPCR) exists and can modulate its biological functions.
- Other names
- PROCRCD201Activated Protein C ReceptorProtein C Receptor
02
Mechanism of action
Enhances activation of protein C, mediates cytoprotective and anti-inflammatory signaling via PAR1.
03
Biological functions
Regulation of coagulationRegulation of inflammationMaintenance of vascular integrityRegulation of stem cell propertiesAnti-apoptotic effectsImmune response modulation
04
Disease associations
ThrombosisAutoimmune conditionsVascular pathologiesCancerInflammation
05
Safety considerations
Loss-of-function mutations lead to placental thrombosis and embryonic lethalityDysregulation implicated in autoimmune conditions and vascular pathologies
06
Biomarkers
sEPCR levels (soluble form)EPCR expression on endothelial cells and hematopoietic stem cells
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