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Endothelin-converting enzyme 1 (ECE-1)
- Target
- ECE-1
- Molecular classification
- Enzyme, Metalloendopeptidase, Zinc-dependent metalloendopeptidase
01
Overview
Endothelin-converting enzyme 1 (ECE-1) is a zinc-dependent metalloendopeptidase that catalyzes the conversion of inactive big endothelins into their active forms, regulating vascular tone. It also degrades neuropeptides, influencing receptor recycling. ECE-1 exists as four isoforms with differing subcellular localizations. Dysregulation of ECE-1 is implicated in cardiovascular diseases like hypertension and atherosclerosis, making it a therapeutic target for conditions involving abnormal vasoconstriction or endothelial dysfunction.
- Other names
- ECE1
02
Mechanism of action
Inhibition of ECE-1 prevents the conversion of big endothelins to active endothelins, reducing vasoconstriction and downstream effects.
03
Biological functions
Regulation of blood pressureModulation of inflammatory responsesPromotion of receptor recycling/resensitizationEndothelin biosynthesisNeuropeptide degradation
04
Disease associations
HypertensionAtherosclerosisCardiovascular diseaseVascular injuryInflammation
05
Safety considerations
Potential for affecting multiple vasoactive peptide pathways.Off-target effects due to broad substrate specificity.
06
Interacting drugs
Phosphoramidon
1 more in the full profile.
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