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Endothelin Receptor A (None)
- Target
- None
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
Endothelin Receptor A (ETA) is a G protein-coupled receptor that primarily mediates the physiological effects of endothelin-1 (ET-1), a potent vasoconstrictor peptide. ETA is predominantly found on vascular smooth muscle cells, where its activation leads to vasoconstriction and increased blood pressure. It is implicated in various cardiovascular and renal diseases.
02
Mechanism of action
ETA receptor antagonism
03
Biological functions
VasoconstrictionSodium retentionCell proliferationSignal transduction
04
Disease associations
HypertensionHeart failureRenal failurePulmonary arterial hypertension
05
Interacting drugs
Bosentan
3 more in the full profile.
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