Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Aneurysm exclusion via endovascular stent graft describes endovascular aneurysm repair (EVAR), a minimally invasive procedure using catheter-deployed stent grafts to treat aortic aneurysms, primarily abdominal aortic aneurysms (AAA) but also thoracic ones. The stent graft, typically composed of nitinol or stainless steel stents sewn to polyester fabric, is inserted via femoral artery incisions under fluoroscopic guidance, expands to seal proximal and distal to the aneurysm, and redirects blood flow to exclude the weakened sac from circulation, reducing rupture risk. This approach avoids open surgery, offering shorter recovery, less pain, and lower perioperative mortality compared to traditional repair, though long-term surveillance is required due to complications like endoleaks—classified into types from attachment failure (Type 1) to unknown endotension (Type 5). FDA-approved devices like Endurant and Zenith systems target aneurysms ≥5 cm with suitable anatomy (e.g., adequate neck length ≥10 mm, minimal angulation). EVAR is standard for many patients but investigational in complex cases; variants include fenestrated (FEVAR) for branched anatomy. No direct drug interactions apply, as it is a mechanical intervention for cardiovascular disease.
Device deploys fabric-covered metal stent via catheter to seal aneurysm sac, bypassing weakened arterial wall
Beyond the preview
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Explore the programs pursuing this target and their development progress.
Follow the clinical studies evaluating therapies directed at this target.
Compare approaches across drug candidates, modalities, and indications.
Investigate the research and source evidence behind target biology and development.
Explore patent activity around therapies and technologies addressing this target.
Connect target biology, drug development, and emerging evidence in your research.
See how Gosset can support your research on Endovascular aneurysm repair (EVAR) (EVAR).