Target intelligence / Profile preview

Endovascular aneurysm repair (EVAR) (EVAR)

Target
EVAR
01

Overview

Aneurysm exclusion via endovascular stent graft describes endovascular aneurysm repair (EVAR), a minimally invasive procedure using catheter-deployed stent grafts to treat aortic aneurysms, primarily abdominal aortic aneurysms (AAA) but also thoracic ones. The stent graft, typically composed of nitinol or stainless steel stents sewn to polyester fabric, is inserted via femoral artery incisions under fluoroscopic guidance, expands to seal proximal and distal to the aneurysm, and redirects blood flow to exclude the weakened sac from circulation, reducing rupture risk. This approach avoids open surgery, offering shorter recovery, less pain, and lower perioperative mortality compared to traditional repair, though long-term surveillance is required due to complications like endoleaks—classified into types from attachment failure (Type 1) to unknown endotension (Type 5). FDA-approved devices like Endurant and Zenith systems target aneurysms ≥5 cm with suitable anatomy (e.g., adequate neck length ≥10 mm, minimal angulation). EVAR is standard for many patients but investigational in complex cases; variants include fenestrated (FEVAR) for branched anatomy. No direct drug interactions apply, as it is a mechanical intervention for cardiovascular disease.

Other names
Endovascular stent graftingEndovascular stent graft placement
02

Mechanism of action

Device deploys fabric-covered metal stent via catheter to seal aneurysm sac, bypassing weakened arterial wall

03

Disease associations

Cardiovascular disease
04

Safety considerations

Endoleaks (Types 1-5)Inadequate fixation or sealingGraft migration or failureEndotensionDevice-specific issues (e.g., porosity in older grafts)Contraindications (e.g., severe angulation >60°, short neck <10 mm, heavy calcification, Marfan syndrome, renal failure)
05

Biomarkers

Patient selection based on imaging (e.g., aneurysm size ≥5 cm, neck length, angulation)

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