Energy metabolism enzyme in Schistosoma species (None established for the entire group; individual enzymes (e.g., enolase, AMPK) have standard abbreviations)

Energy metabolism enzymes in Schistosoma species refer to a heterogeneous group of enzymes that catalyze critical steps in glucose uptake, glycolysis, the Krebs cycle, and related metabolic pathways, enabling the parasite’s energetic needs throughout its life cycle. Notable enzymes include enolase, AMP-activated protein kinase (AMPK), and surface phosphatases (such as SmAP), which contribute to both energy extraction from host-derived glucose and metabolic adaptation to varied environments. These enzymes are essential for parasite survival, growth, and pathogenesis, making them attractive targets for anti-schistosomiasis therapies. Many approved and experimental drugs have been identified to interact with specific metabolic enzymes, validating their druggability. However, the lack of selectivity may pose challenges for host safety due to the evolutionary conservation of these enzymes.

Other names

Schistosoma energy metabolism enzymeSchistosome metabolic enzymeSchistosoma glycolytic enzymeMitochondrial enzyme (in Schistosoma)Schistosoma glycolysis enzyme

Enzymatic inhibition (reduces energy production and parasite survival); Inhibition of glycolysis and Krebs cycle enzymes; Disruption of ATP production; Interference with metabolic adaptation (e.g., AMPK inhibition, glycolytic flux modification)