Energy metabolism support (null)

Energy metabolism support" refers to the network of metabolic pathways (mainly glycolysis, citric acid cycle/TCA cycle, oxidative phosphorylation, fatty acid oxidation, and amino acid catabolism) that cells use to generate ATP from nutrients. This collection of pathways does not represent a single protein, receptor, or defined molecular target, but rather a set of processual targets that can be influenced pharmacologically or by disease states. These pathways are tightly regulated, highly interconnected, and essential for cell survival, growth, and function. Therapeutic modulation of energy metabolism can be important in treating diseases like cancer, cardiovascular disorders, metabolic syndrome, and mitochondrial diseases, but indiscriminate alteration risks severe cellular dysfunction.

Other names

energy metabolismmetabolic supportcellular bioenergeticsmetabolic pathways

Inhibition or activation of key enzymes in glycolysis, TCA cycle, and OXPHOS; modification of mitochondrial function; and redirecting substrate utilization (glucose, fatty acids, amino acids).