Engineered ARC-tag domain of SPRX002 protein

The **engineered ARC-tag** is a functional protein domain incorporated into SPRX002, a soluble protein developed in the Arcellx ARC-sparX platform. SPRX002 contains two main regions: the TAG region, recognized by engineered ARC-T cells, and the CD123-binding region that targets antigen-positive cancer cells, particularly in acute myeloid leukemia[3][5][2][6]. The ARC-tag facilitates binding by ARC-T cells, linking them to SPRX002-coated malignant cells for selective immune-mediated cytotoxicity. The ARC-tag itself is not a natural or canonical therapeutic target but is critical as a modular component of the ARC-sparX cell therapy system[3][6][8]. If the intention is to document the canonical disease target for ARC-sparX therapy, the entry should be "CD123" (Interleukin-3 receptor alpha chain), not the engineered ARC-tag. The ARC-tag is an enabling technology, not a disease-driving molecule or receptor.

Other names

TAG domain of SPRX002ARC tagsparX tag